APID COMMUNICATION argeting Mucosal Addressin Cellular Adhesion Molecule MAdCAM)-1 to Noninvasively Image Experimental Crohn’s isease
نویسندگان
چکیده
HRISTOPHER BACHMANN,* ALEXANDER L. KLIBANOV, TIMOTHY S. OLSON, ASON R. SONNENSCHEIN,* JESUS RIVERA–NIEVES,* FABIO COMINELLI,* KLAUS F. LEY, ONATHAN R. LINDNER, and THERESA T. PIZARRO* Division of Gastroenterology and Hepatology/Digestive Health Center of Excellence, Department of Biomedical Engineering, Division of ardiovascular Medicine, and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia
منابع مشابه
Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1.
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that mediates recruitment of lymphocytes into the gut mucosa. Attenuation of excessive expression of MAdCAM-1 in the inflamed mucosa could be useful for treatment of inflammatory bowel diseases. The aim of this study was to investigate whether anti-MAdCAM-1 antibody has a prophylactic effect on experimental colitis in...
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Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a homing receptor preferentially expressed on gut-associated endothelial cells that plays a central role in leukocyte traffic into the mucosal immune compartment. Although the molecular mechanisms underlying endothelial ICAM-1 or E-selectin expression have been intensively investigated, the mechanisms that regulate human MAdCAM-1 expressi...
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Induction of mucosal immunity, particularly to subunit vaccines, has been problematic. The primary hurdle to successful mucosal vaccination is the effective delivery of vaccine antigen to the mucosal associated lymphoid tissue. Physical and chemical barriers restrict antigen access and, moreover, immune responses induced in the mucosa can be biased towards tolerance or non-reactivity. We propos...
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